Abdelaal AM, Sohal IS, Iyer SG, Sudarsahn K, Orellana EA, et al. (2024). Molecular Therapy Nucleic Acids, (35)-2. PMID: TBD
Publications
All Publications
Structural basis of regulated m7G tRNA modification by METTL1-WDR4
Authors: Li J, Wang L, Hahn Q, Nowak RP, Viennet T, Orellana EA, et al.(2023). Nature. Jan;613(7943):391-397. doi: 10.1038/s41586-022-05566-4. Epub 2023 Jan 4. PMID: 36599985.
tRNA dysregulation and disease
Orellana, E.A., Siegal, E., and Gregory, R.I. (2022). Nat Rev Genet. PMID: 35681060
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
Orellana, E.A., et al. (2021). Mol Cell 81, 3323-3338.e3314. PMID: 34352207
METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing
Chen, H., Gu, L., Orellana, E.A., et al. (2020). Cell Res 30, 544-547. PMID: 31913360
Identification and validation of microRNAs that synergize with miR-34a – a basis for combinatorial microRNA therapeutics
Orellana, E.A., et al. (2019). Cell Cycle 18, 1798-1811. PMID: 31258013
Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias
Hinze, L., Pfirrmann, M., Karim, S., Degar, J., McGuckin, C., Vinjamur, D., Sacher, J., Stevenson, K.E., Neuberg, D.S., Orellana, E., et al. (2019). Cancer Cell 35, 664-676.e667. PMID: 30991026
Enhancing MicroRNA Activity through Increased Endosomal Release Mediated by Nigericin
Orellana, E.A., et al. (2019). Mol Ther Nucleic Acids 16, 505-518. PMID: 31071527
New Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K(+)/H(+) Exchange
Rangasamy, L., Chelvam, V., Kanduluru, A.K., Srinivasarao, M., Bandara, N.A., You, F., Orellana, E.A., et al. (2018). Bioconjug Chem 29, 1047-1059. PMID: 29446616
FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer
Orellana, E.A., Tenneti, S., Rangasamy, L., Lyle, L.T., Low, P.S., and Kasinski, A.L. Sci Transl Med 9. PMID: 28768807
Sulforhodamine B (SRB) Assay in Cell Culture to Investigate Cell Proliferation
Orellana, E.A., and Kasinski, A.L. (2016). Bio Protoc 6. PMID: 28573164
MicroRNAs in Cancer: A Historical Perspective on the Path from Discovery to Therapy
Orellana, E.A., and Kasinski, A.L. (2015). Cancers (Basel) 7, 1388-1405. PMID: 26226002
A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer
Kasinski, A.L., Kelnar, K., Stahlhut, C., Orellana, E., Zhao, J., Shimer, E., Dysart, S., Chen, X., Bader, A.G., and Slack, F.J. Oncogene 34, 3547-3555. PMID: 25174400