Ali RH, Orellana EA, Lee SH, Chae YC, Chen Y, Clauwaert J, Kennedy AL, Gutierrez AE, Papke DJ, Valenzuela M, Silverman B, Falzetta A, Ficarro SB, Marto JA, Fletcher CDM, Perez-Atayde A, Alcindor T, Shimamura A, Prensner JR, Gregory RI, Gutierrez A. A...
Publications
Publications
Selective targeting of chemically modified miR-34a to prostate cancer using a small molecule ligand and an endosomal escape agent
Abdelaal AM, Sohal IS, Iyer SG, Sudarshan K, Orellana EA, Ozcan KE, Dos Santos AP, Low PS, Kasinski AL. Selective targeting of chemically modified miR-34a to prostate cancer using a small molecule ligand and an endosomal escape agent. Mol Ther Nucleic Acids. 2024 Apr...
Structural basis of regulated m7G tRNA modification by METTL1-WDR4
Authors: Li J, Wang L, Hahn Q, Nowak RP, Viennet T, Orellana EA, et al.(2023). Nature. Jan;613(7943):391-397. doi: 10.1038/s41586-022-05566-4. Epub 2023 Jan 4. PMID: 36599985.
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
Orellana, E.A., et al. (2021). Mol Cell 81, 3323-3338.e3314. PMID: 34352207
METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing
Chen, H., Gu, L., Orellana, E.A., et al. (2020). Cell Res 30, 544-547. PMID: 31913360
Identification and validation of microRNAs that synergize with miR-34a – a basis for combinatorial microRNA therapeutics
Orellana, E.A., et al. (2019). Cell Cycle 18, 1798-1811. PMID: 31258013