tRNA-centric view
of biological processes

Orellana Lab

Orellana Lab What we Do

What we do

The Orellana Lab studies the causes and effects of tRNA dysregulation in human disease and uses this knowledge to develop diagnostics and tRNA-based therapeutics.

Orellana Lab Why we Do It
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Why we do it

For many years, the contribution of tRNAs to human disease has been overlooked. Accumulating evidence indicates that the dynamic nature of tRNA modifications and composition of the tRNA pool can contribute to human diseases including cancer.

Orellana Lab How we do it

How we do it

Our primary focus is to understand tRNA biology using cell culture and mouse models. We employ bioinformatic, genetic, molecular, biochemical, and cell biological approaches to probe how perturbation of tRNAs results in disease.

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