tRNA-centric view
of biological processes
Orellana Lab
What we do
The Orellana Lab studies the causes and effects of tRNA dysregulation in human disease and uses this knowledge to develop diagnostics and tRNA-based therapeutics.
Why we do it
For many years, the contribution of tRNAs to human disease has been overlooked. Accumulating evidence indicates that the dynamic nature of tRNA modifications and composition of the tRNA pool can contribute to human diseases including cancer.
How we do it
Our primary focus is to understand tRNA biology using cell culture and mouse models. We employ bioinformatic, genetic, molecular, biochemical, and cell biological approaches to probe how perturbation of tRNAs results in disease.